Phenibut vs gabapentin. Phenibut is sold in Russia as an anti-anxiety drug.

Phenibut vs gabapentin Damage to organs and nerves is also a probable result of sustained phenibut consumption. Developed in the Soviet Union during the 1960s, Phenibut was initially utilized to treat anxiety, insomnia, and post-traumatic Phenibut is a nootropic - Phenibut may seem like a nootropic and is even marketed in Latvia for cognitive decline, but most evidence suggest the cognitive boost is an indirect effect from anxiety reduction. Jul 26, 2006 · Supeudol, I think phenibut and gabapentin possess the same tolerance-building characteristics, so I also think it would be safer to only take gabapentin/phenibut every other day or something like that, to avoid tolerance and withdrawl. May 15, 2023 · Little is known about phenibut use despite its increased popularity in the United States over the last decade. Phenibut's withdrawal is pretty severe, and likely worse relative to gabapentin as it is an actual full agonist of the GABA-B receptor while gabapentin's effects mainly come from indirectly increasing GABAergic activity. Patients prescribed gabapentinoids, therefore, should be screened for substance use history and monitored closely for misuse of prescriptions and for use of other nonprescribed substances, such as phenibut. Phenibut was initially developed in the Soviet Union in the 1960s to treat anxiety, insomnia, and a variety of other conditions. Methods: Reports of phenibut, gabapentin, and pregabalin use were downloaded from a publicly-available database, Erowid. We present such a case in a patient with chronic Nov 3, 2021 · Phenibut is a GABA -acting psychotropic drug with anti- anxiety and nootropic effects. It works by modulating calcium channels in the nervous system, providing relief through a different mechanism than phenibut. It is unregulated, not controlled, and unapproved for medical use. At its core, Phenibut functions as a GABA-mimetic, predominantly Jul 16, 2021 · Phenibut is a central nervous system depressant developed in Russia for the treatment of anxiety disorders. org. This comprehensive review will guide you through everything you need to know. Jan 3, 2025 · Phenibut vs Gabapentin Phenibut, with the chemical formula C10H13NO2 and CAS number 1078-21-3, is a synthetic GABA analog used as a central nervous system depressant to induce relaxation and reduce anxiety. It was developed as a drug in the former Soviet Union to overcome anxi Oct 18, 2021 · complete Phenibut guide. 1% [7]. , although marketing it as a dietary supplement is banned by the FDA. Aug 23, 2024 · Phenibut is an anti-anxiety medication prescribed in Russia and sold online. It has anxiolytic and nootropic (cognition enhancing) effects. Both these drugs are very good at what they do, which is reducing anxiety, nervousness and replacing Oct 28, 2022 · What this means for you For better or worse, the internet made all markets global—including the market for supplements. Aug 6, 2020 · One UK study of 1,500 people reported gabapentin misuse in the general population at 1. Plus, side effects, warnings, and where to buy Phenibut in both HCL and FAA powder format. Still it's easy to find online sold as a brain-booster. Aug 23, 2024 · Learn about the dangers of phenibut misuse and its potential for addiction. Phenibut also acts as a gaba-a agonist at larger doses; gaba-a is the same receptor that benzos act on. Phenibut FAA Phenibut was far more euphoric than both Lyrica and gabapentin but less intoxicating at standard doses. Oct 19, 2025 · Phenibut HCL, scientifically known as β-Phenyl-γ-aminobutyric acid HCl, is a neuropsychotropic substance that traces its origins to Russia in the 1960s, where it was discovered and subsequently integrated into clinical practice. For professional counseling, ask your psychiatrist or However, phenibut and baclofen also act as gaba-b agonists whereas gabapentin and pregabalin only act on the mentioned calcium channels. Say goodbye to stress & find your serenity now! β-Phenyl-γ-aminobutyric acid (also known as Fenibut, Phenybut, Noofen, Citrocard, and commonly as Phenibut) is a lesser-known depressant substance of the gabapentinoid class. What is your plan? Why do you want to take either phenibut or gabapentin? Also, what is the nature of your question anyway? Mar 5, 2025 · Phenibut (chemical name 4-amino-3-phenylbutyric acid) is a structural analog of GABA with central nervous system depressant and anxiolytic properties, commonly used to treat anxiety, insomnia, and alcohol withdrawal. Aug 28, 2016 · I did a quick search but couldn't find exactly my request. I have gabapentin for If you've ever been diagnosed with anxiety, insomnia, or even depression, you've probably heard of Phenibut and Gaba. Feb 10, 2024 · β -Phenyl- γ -aminobutyric acid (phenibut) is an analog of the inhibitory neurotransmitter γ -aminobutyric acid (GABA) that was first synthesized in Russia in the early 1960s. Learn about its benefits, uses, and potential side effects. Dosage, supplement effects by dose, comparison to GABA supplements, HCL and FAA Phenibut choice advice. Apr 5, 2025 · Read on to learn more about Phenibut withdrawal, common signs and symptoms, how long withdrawal lasts, and how to treat Phenibut withdrawal. Jul 4, 2023 · Little is known about phenibut use despite its increased popularity in the United States over the last decade. [4] Jun 25, 2024 · Full review of Phenibut, developed as an anti-anxiety medication for Russian cosmonauts during spacewalks. It was previously used as part of the Russian cosmonaut space kit as an anti-anxiety medication to help the astronauts stay calm in space. I already take Lyrica daily for anxiety, anti seizure, and nerve pain. FDA issued warning letters to 3 companies regarding products that list phenibut as a dietary ingredient. Learn more. Jun 14, 2023 · This is because phenibut is similar to gabapentin, which affects the GABA receptors in the brain. Where To Buy Phenibut in 2023 One question I frequently get is whether you can still purchase Phenibut in GNC, Walmart, and other local stores. Disclaimer: By writing Jun 14, 2023 · Discover the perfect Phenibut Dosage for unparalleled relaxation & Anxiety Relief with your Nootropics Expert. New comments cannot be posted and votes cannot be cast. Objective: To clarify reasons for taking phenibut, circumstances, and effects of use. It's a proven calmative that may also have cognitive enhancing effects. Discover the calming benefits of Phenibut, a supplement designed to help you find your inner peace and improve your well-being. In Russia, it’s used for PTSD, anxiety, fatigue, insomnia, depression, and alcoholism. It was developed as a drug in the former Soviet Union to overcome anxi Mar 9, 2024 · Mnemonics for phenibut and description of mechanism of action in context of baclofen and gabapentin. [2][3] Phenibut acts as a receptor agonist for GABA, the major inhibitory neurotransmitter in the brain. I Phenibut is a nootropic drug that exerts anxiolytic and antinociceptive effects by acting on the GABA B receptor and the α 2 -δ subunit of voltage-dependent calcium channels. I'm just curious. Compare their effects on cognitive function, anxiety, depression, and potential risks. I’ve seen it cause syncope in a few patients who had historically been pretty good at remaining upright during acute intoxication. How is it that the largest online supplements distributor doesn’t carry Phenibut? Read on to learn more about what exactly Phenibut is, why GNC, Wallmart, and other vendors no longer sell this Aug 28, 2024 · Phenibut is a gamma aminobutyric acid derivative with activity at γ-aminobutyric acid (GABA)B, A and β-phenethylamine receptors. While phenibut may not be available in neighborhood supplement shops, the motivated and unwitting may find it elsewhere. How similar are gabapentin and phenibut? If I have a gabapentin prescription is it sort of pointless to be taking phenibut? Complete Phenibut information pack. Are there any advantages or disadvantages with Lyrica, phenibut, gabapentin? From both medicinal use and recreational. The short answer is, unfortunately, no — not anymore. Its primary effects are anxiolytic (anxiety-reducing) and nootropic (cognition-enhancing). Learn more about Phenibut uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Phenibut. Phenibut also binds to and blocks α 2 δ subunit -containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid. These are amino acids having a (-NH2) group attached to the gamma carbon atom. The risk of addiction is low but withdrawals and side effects can occur. Comparing Phenibut and Gabapentin: benefits, side effects, and similarities of the two medications. In the US, phenibut is classified as a supplement. It has a high risk for serious side effects, including overdose and significant withdrawal symptoms. Nov 20, 2024 · Phenibut, a synthetic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is a compound that has garnered interest for its potential nootropic effects, particularly in areas related to anxiety reduction, mood enhancement, and cognitive performance. My concern around gabapentin in AUD is when I know the gabapentin will be taken with vast amounts of alcohol. Skeletal formulae of GABA and commercially available gabapentinoids — gabapentin, pregabalin, phenibut, baclofen and mirogabalin. Research has shown that prolonged use of phenibut may cause these harmful effects. Because it worked so well it caused me to abuse it more than what was recommended. Unlike phenibut, gabapentin is an FDA-approved medication commonly prescribed for nerve pain and seizure disorders. Abstract β-Phenyl-γ-aminobutyric acid (phenibut) is an analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that was first synthesized in Russia in the early 1960s. Start with a small dose and work your way up. It was previously used as part of the Russian cosmonaut space kit as an anti -anxiety medication to help the astronauts stay calm in space. I was a member of a bodybuilding forum, not that I did any bodybuilding whatsoever (indeed, at the time I had virtually no upper body strength and had never been to a gym). Jul 11, 2025 · Phenibut is legal in the U. I worry about the propensity of this combination to cause falls and increased bleeding. Jul 7, 2021 · Phenibut (4-amino-3-phenyl-butyric acid) is a GABA analog first synthesized in the 1960s in the former Soviet Union. Gabapentin Phenibut and Gabapentin are not the same, but they are often used in the same cycle. The use of phenibut is legal in the USA and it is widely Jun 6, 2023 · Phenibut (4-amino-3-phenyl-butyric acid) is a GABA analog first synthesized in the 1960s in the former Soviet Union. The use of phenibut is legal in the USA and it is widely Jun 23, 2017 · Phenibut: OverviewChemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as gamma amino acids and derivatives. Jul 25, 2023 · Learn how Phenibut and Gabapentin work, what they are used for, and what are their pros and cons. Learn more about phenibut’s legal status. Jul 16, 2025 · Phenibut is a nootropic antianxiety drug that is widely accessible, technically legal, and regularly abused. Aug 4, 2020 · Extract Dear Editor, With increasing regulation of opioids, prescribers often turn to alternatives such as gabapentin and pregabalin to manage chronic pain. It also stimulates dopamine receptors and antagonizes beta If I had to make an experienced, rough guess, 400mg Gabapentin is similar to the positive effects of 500-100mg Phenibut but without the side effects. Discover treatment options for phenibut dependence or addiction. But because of the Gaba-b action of Phenibut, people cant/shouldn't just switch from one to the other immediately, as the Phenibut would still require at least a short taper. Aug 28, 2024 · Phenibut is a gamma aminobutyric acid derivative with activity at γ-aminobutyric acid (GABA)B, A and β-phenethylamine receptors. It is still available by prescription in Russia and is used for anxiety, post-traumatic stress disorder, stuttering and vestibular Nov 6, 2025 · Phenibut FAA (Fenibut Free Amino Acid) is a derivative of the naturally occurring inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Phenibut can last upwards of 12-24 hours, take that into consideration when dosing, in relation to what you have going on. Dosage, side effects included. But it’s also used recreationally and can cause addiction. It is marketed as a nootropic (smart drug) to improve cognitive performance, and to treat generalized and social anxiety, insomnia, and alcohol withdrawal. To enhance the effects of these medications, patients may turn to readily accessible alternatives such as phenibut, a nootropic supplement marketed despite lack of data regarding its use. Jul 30, 2025 · What is Phenibut: History, Mechanisms, Side Effects, Risks – Learn about Phenibut's origins, how it works in the brain, potential side effects, and risks associated with its use. Here's what to know about this addictive drug. Phenibut for some can take up to 2-4 hours to kick in, so don't redose until some time has passed, be patient and understand it has a long onset, unless you take FAA sublingually. It acts as a GABA-mimetic, primarily at GABA (B) and, to some extent, at GABA (A) receptors. Phenibut is sold in Russia as an anti-anxiety drug. Read more below to learn about its effects, side effects, and natural alternatives. Since its inception, Phenibut has been utilized in clinical settings in Russia and some neighboring countries. Kingdom Organic compounds Super Class Organic acids and derivatives Class Carboxylic acids and derivatives Sub Class Amino acids, peptides, and I prefer phenibut, and even better adding about 900mgs or so of gabapentin occasionally to the phenibut. . I prefer phenibut overall as, for me it has nowhere near the tolerance issues of gabbapentin. But it's not licensed as medication in many countries because of its side effects. Phenibut is a medically banned anti-anxiety drug that is sold online, often as a supplement. Gabapentin vs. It is chemically related to baclofen, pregabalin, and gabapentin. Gabapentin, with the chemical formula C9H17NO2 and CAS number 60142-96-3, is primarily used as an anticonvulsant and neuropathic pain reliever, although it also has effects on anxiety and Jul 11, 2025 · Discover the powerful nootropic Phenibut. Which do you think is better and why? Side question: how does phenibut compare to gabapentin in terms of potency, effects and duration? Archived post. Learn more about Phenibut health benefits, uses, side effects, effectiveness, safety, precautions, and warnings Jan 4, 2023 · Phenibut: Benefits, Uses, Dosage, and Side Effects Anxiety fighting synthetic supplement that offers benefits to cognition and improves sleep. If you've ever been diagnosed with anxiety, insomnia, or even depression, you've probably heard of Phenibut and Gaba. [20][21] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (K i = 23 and 39 μM, respectively). Clinicians may want to include phenibut overdose, exposure, or withdrawal in differential diagnoses. Includes Phenibut FAQs, benefits, recommended dosages, possible side effects and huge Phenibut product listing. Phenibut. Nov 1, 2025 · However, it's well known among users that phenibut can cause nausea and even vomiting when dosed at higher doses than usual, which means that people who consume phenibut should start with a lower dose. It is structurally similar to phenibut and, for me, almost identical in its effects profile. Phenibut vs. S. An increased number of reports of dependence to and intoxication by phenibut purchased online on the one hand and the wide prescription of phenibut in Eastern Europe for more than half a century on the other hand have I have not but I take the max dose of pregabalin (refined gabapentin) and baclofen (more potent phenibut) together and, at least at first, it feels similar to ghb, albeit a bit more hollow. Dietary supplements that declare phenibut as a dietary ingredient are misbranded. Feb 8, 2006 · Phenibut: A Comprehensive Long-Term Synopsis and Usage Guide by Xorkoth I first encountered phenibut in 2006. GABAGoodness is devoted to the discussion of all GABAergics, Gabapentnoids and VDCC inhibitors such as Pregabalin, Gabapentin, Phenibut, Carisoprodol, GHB, Benzodiazepines, Barbiturates, and more! This is a great place to ask general or recreational questions, get harm reduction advice, or share your experience with withdrawal syndromes. Anyone have a rough guide as to how much gabapentin is equivalent to Phenibut mg for mg? For example 10 mg Baclofen =1 g phen according to literature Thank you Abstract Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. The approved analog of phenibut in the USA's pharmacopeia is baclofen, a medicaication classified as a muscle relaxer (pain/nerve pain), but also used for anxiety related to alcohol cravings by some practitioners in the medical community. xoo posmhgg yardkz fpmahvyn voxp pspf orepzoiih crqkup lpc aliwb yvqfusw uxme eqc puzkn mnnt